![]() Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. ![]() ![]() The book will give counselors the information that will enable them to help concerned parents accommodate to their particular "chromosomal situation", and to determine what may be, for them, the best course of action. The practical applications of recent advances in molecular cytogentics are noted. New chapters have been written on preimplantation diagnosis and on reproductive risks due to environmental agents. This third edition has been thorougly updated, and is richly illustrated and fully referenced. These and other questions concerning chromosome abnormalities are addressed in this standard text, which will be of interest to genetic counselors, medical geneticists, pediatricians and obstetricians, infertility specialists, and laboratory cytogeneticists. They may want to know the outlook for a pregnancy, and what the risks might be. There may have been a history of multiple miscarriage, or infertility. Many parents and couples seek genetic counseling in order to learn why they, or a relative, may have had a child with a particular collection of medical problems and/or intellectual disability. McKinlay GardnerĬhromosomal abnormalities can cause disability in children, and reproductive difficulty in parents. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.Ĭhromosome Abnormalities And Genetic Counseling by R. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. These take-home resources are critical to helping both providers and patients understand some of the basic concepts and applications of genetics and genomics.Ĭhromosomal Translocations And Genome Rearrangements In Cancer by Janet D. Appendices can be copied for reference and offered to patients. At the end of each section, a list of references is provided for additional information. Resources are included to assist in patient care, patient and professional education, and identification of specialty genetics services within the New York - Mid-Atlantic region. It also provides information about diagnosis of genetic disease, family history, newborn screening, and genetic counseling. The manual begins with a basic introduction to genetics concepts, followed by a description of the different types and applications of genetic tests. The purpose of this manual is to provide an educational genetics resource for individuals, families, and health professionals in the New York - Mid-Atlantic region and increase awareness of specialty care in genetics. We only index and link to content provided by other sites. Disclaimer: This site does not store any files on its server.
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